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Homo-PROTAC pVHL30 degrader 1

CAS No. 2244684-49-7

Homo-PROTAC pVHL30 degrader 1( —— )

Catalog No. M24022 CAS No. 2244684-49-7

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 147 In Stock
25MG 295 In Stock
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Biological Information

  • Product Name
    Homo-PROTAC pVHL30 degrader 1
  • Note
    Research use only, not for human use.
  • Brief Description
    Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.
  • Description
    Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    E3 Ligase Ligand
  • Recptor
    VHL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2244684-49-7
  • Formula Weight
    1179.45
  • Molecular Formula
    C58H82N8O14S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (127.18 mM)
  • SMILES
    O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.
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